New research is showing that the problem in ALS comes from oxidative damage to the brain and the nerves.  Free radicals react to damage individual cells.  Excess iron and maybe excess copper may make the problem worse. 

Zinc and copper compete in the body, so increased consumption of zinc may help to flush out excess copper.  The primary free radical damage seems to come from hydrogen peroxide made from contact with the iron or copper.  Thus, high doses of vitamin C may be more effective than high doses of vitamin E, which acts primarily on oils in the body.

Selenium, an important part of glutathione peroxidase, a major antioxidant, is deficient in many with ALS, and supplementation may make a difference.  Folic acid, which neutralizes homocysteine, may also be important.   There is evidence that CoQ-10 and melatonin are also of benefit due to the mitochondrial damage which is an important part of ALS. 

Also, part of the damage seems to be related to magnesium deficiency and and calcium deposits in soft tissue.  Additional vitamin D and supplemental magnesium are indicated for this problem.

If you would like to learn more about the research, click here.